Obesity Impairs the Action of the Neuroendocrine Ghrelin System
Identifieur interne : 002A68 ( Main/Exploration ); précédent : 002A67; suivant : 002A69Obesity Impairs the Action of the Neuroendocrine Ghrelin System
Auteurs : Jeffrey M. Zigman [États-Unis] ; Sebastien G. Bouret [États-Unis, France] ; Zane B. Andrews [Australie]Source :
- Trends in endocrinology and metabolism: TEM [ 1043-2760 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Ghréline, Obésité.
- physiologie : Métabolisme énergétique, Poids du corps.
- physiopathologie : Obésité.
- Animaux, Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Ghrelin.
- metabolism : Obesity.
- physiology : Body Weight, Energy Metabolism.
- physiopathology : Obesity.
- Animals, Humans.
Abstract
Ghrelin is a metabolic hormone that promotes energy conservation by regulating appetite and energy expenditure. Although some studies suggest that antagonizing ghrelin function attenuates body weight gain and glucose intolerance on a high calorie diet, there is little information about the metabolic actions of ghrelin in the obese state. In this review, we discuss the novel concept of obesity-induced central ghrelin resistance in neural circuits regulating behavior, and impaired ghrelin secretion from the stomach. Interestingly, weight loss restores ghrelin secretion and function, and we hypothesize that ghrelin resistance is a mechanism designed to protect a higher body weight set-point established during times of food availability, to maximize energy reserves during a time of food scarcity.
Url:
DOI: 10.1016/j.tem.2015.09.010
PubMed: 26542050
PubMed Central: 4814209
Affiliations:
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Le document en format XML
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Although some studies suggest that antagonizing ghrelin function attenuates body weight gain and glucose intolerance on a high calorie diet, there is little information about the metabolic actions of ghrelin in the obese state. In this review, we discuss the novel concept of obesity-induced central ghrelin resistance in neural circuits regulating behavior, and impaired ghrelin secretion from the stomach. Interestingly, weight loss restores ghrelin secretion and function, and we hypothesize that ghrelin resistance is a mechanism designed to protect a higher body weight set-point established during times of food availability, to maximize energy reserves during a time of food scarcity.</p></div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Los Angeles</li></settlement><orgName><li>Université de Californie du Sud</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Zigman, Jeffrey M" sort="Zigman, Jeffrey M" uniqKey="Zigman J" first="Jeffrey M." last="Zigman">Jeffrey M. Zigman</name></noRegion><name sortKey="Bouret, Sebastien G" sort="Bouret, Sebastien G" uniqKey="Bouret S" first="Sebastien G." last="Bouret">Sebastien G. Bouret</name></country><country name="France"><noRegion><name sortKey="Bouret, Sebastien G" sort="Bouret, Sebastien G" uniqKey="Bouret S" first="Sebastien G." last="Bouret">Sebastien G. Bouret</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Andrews, Zane B" sort="Andrews, Zane B" uniqKey="Andrews Z" first="Zane B." last="Andrews">Zane B. Andrews</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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